3D - EX SM
A comprehensive approach to drug discovery
The ultimate holistic approach to drug development. Building on 3D-ScreenSM and 3D-EXploreSM, 3D-EXSM includes more capabilities to discover more about drug mechanism of action and identify biomarkers for clinical applications using our fresh patient 3D tumoroids.
Our customizable 3D-EXSM platform uses cutting-edge technologies in high content imaging, Nanostring gene expression profiling, flow cytometry, multiplex cytokine assays, mass spectrometry, multiplex immunohistochemistry and more.
3D-EXSM can also be used in a clinical trial setting on fresh tumor biopsy samples to help develop biomarkers of response for future clinical applications.
- Assess the binding and efficacy of bi-specifics in solid tumors
- Perform real-time monitoring of cell viability and cell death by high-content imaging combined with multiplex cytokine analysis
- Analyze drug effects on all components of the tumor microenvironment, including the extracellular matrix
- Test drug effect on tumor cell killing and T-cell activation
- Analyze the immunostimulatory activity of rational combination treatments at single or multiple drug concentrations
- Test the efficacy of immune checkpoint inhibitors, both antibody-based and small molecule
- Monitor ex vivo T-cell trafficking and infiltration in response to immuno-modulators and anticancer drugs in individual patient tumors
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